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Cellosaurus K-562 SimpleCell O-GalNAc (CVCL_S029)

[Text version]
Cell line name K-562 SimpleCell O-GalNAc
Synonyms K562 SimpleCell; K562 SC
Accession CVCL_S029
Resource Identification Initiative To cite this cell line use: K-562 SimpleCell O-GalNAc (RRID:CVCL_S029)
Comments Population: Caucasian.
Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=21983924; DOI=10.1038/nmeth.1731
Steentoft C., Vakhrushev S.Y., Vester-Christensen M.B., Schjoldager K.T.-B.G., Kong Y., Bennett E.P., Mandel U., Wandall H.H., Levery S.B., Clausen H.
Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines.
Nat. Methods 8:977-982(2011)

PubMed=23399548; DOI=10.1074/mcp.O112.021972
Vakhrushev S.Y., Steentoft C., Vester-Christensen M.B., Bennett E.P., Clausen H., Levery S.B.
Enhanced mass spectrometric mapping of the human GalNAc-type O-glycoproteome with SimpleCells.
Mol. Cell. Proteomics 12:932-944(2013)

PubMed=23584533; DOI=10.1038/emboj.2013.79
Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T.-B.G., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
EMBO J. 32:1478-1488(2013)

Cross-references
Encyclopedic resources Wikidata; Q54899217
Entry history
Entry creation05-Nov-2013
Last entry update29-Jun-2023
Version number20