ID   MDA-MB-231 SimpleCell O-GalNAc
AC   CVCL_S031
SY   MDA-MB-231 SimpleCell; MDA-MB-231 SC
DR   cancercelllines; CVCL_S031
DR   Wikidata; Q54904590
RX   PubMed=23584533;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
CC   Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0062 ! MDA-MB-231
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 24
//
RX   PubMed=23584533; DOI=10.1038/emboj.2013.79;
RA   Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y.,
RA   Vester-Christensen M.B., Schjoldager K.T.-B.G., Lavrsen K.,
RA   Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P.,
RA   Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.;
RT   "Precision mapping of the human O-GalNAc glycoproteome through
RT   SimpleCell technology.";
RL   EMBO J. 32:1478-1488(2013).
//