Cellosaurus MDA-MB-231 SimpleCell O-GalNAC/O-Man (CVCL_S032)

Cell line name MDA-MB-231 SimpleCell O-GalNAC/O-Man
Accession CVCL_S032
Resource Identification Initiative To cite this cell line use: MDA-MB-231 SimpleCell O-GalNAC/O-Man (RRID:CVCL_S032)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Characteristics: Cell engineered to produce only truncated GalNAc, NeuAc-alpha-2-6-GalNAc and Man O-glycans.
Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
Knockout cell: Method=ZFN; HGNC; 19139; POMGNT1.
Sequence variation: Heterozygous for BRAF p.Gly464Val (from parent cell line).
Sequence variation: Heterozygous for KRAS p.Gly13Asp (from parent cell line).
Sequence variation: Homozygous for TP53 p.Arg280Lys (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S031 (MDA-MB-231 SimpleCell O-GalNAc)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=24101494; DOI=10.1073/pnas.1313446110
Vester-Christensen M.B., Halim A., Joshi H.J., Steentoft C., Bennett E.P., Levery S.B., Vakhrushev S.Y., Clausen H.
Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.
Proc. Natl. Acad. Sci. U.S.A. 110:21018-21023(2013)