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Cellosaurus MDA-MB-231 SimpleCell O-GalNAC/O-Man (CVCL_S032)

Cell line name MDA-MB-231 SimpleCell O-GalNAC/O-Man
Accession CVCL_S032
Resource Identification Initiative To cite this cell line use: MDA-MB-231 SimpleCell O-GalNAC/O-Man (RRID:CVCL_S032)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Characteristics: Cell engineered to produce only truncated GalNAc, NeuAc-alpha-2-6-GalNAc and Man O-glycans.
Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
Knockout cell: Method=ZFN; HGNC; 19139; POMGNT1.
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S031 (MDA-MB-231 SimpleCell O-GalNAc)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

PubMed=24101494; DOI=10.1073/pnas.1313446110
Vester-Christensen M.B., Halim A., Joshi H.J., Steentoft C., Bennett E.P., Levery S.B., Vakhrushev S.Y., Clausen H.
Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.
Proc. Natl. Acad. Sci. U.S.A. 110:21018-21023(2013)

Other Wikidata; Q54904591