Cellosaurus OVCAR-3 SimpleCell O-GalNAc (CVCL_S033)

Cell line name OVCAR-3 SimpleCell O-GalNAc
Synonyms OVCAR-3 SimpleCell; OVCAR-3 SC
Accession CVCL_S033
Resource Identification Initiative To cite this cell line use: OVCAR-3 SimpleCell O-GalNAc (RRID:CVCL_S033)
Comments Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
Sequence variation: Homozygous for TP53 p.Arg248Gln (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0465 (OVCAR-3)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=23584533; DOI=10.1038/emboj.2013.79
Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
EMBO J. 32:1478-1488(2013)