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Cellosaurus MDA-MB-231/5-FU (CVCL_S511)

[Text version]

Cell line name MDA-MB-231/5-FU
Accession CVCL_S511
Resource Identification Initiative To cite this cell line use: MDA-MB-231/5-FU (RRID:CVCL_S511)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Selected for resistance to: ChEBI; CHEBI:46345; 5-fluorouracil (5-FU).
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (ClinVar=VCV000040364) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (ClinVar=VCV000376657) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=24126575; DOI=10.3892/ijo.2013.2135
Takahashi K., Tanaka M., Inagaki A., Wanibuchi H., Izumi Y., Miura K., Nagayama K., Shiota M., Iwao H.
Establishment of a 5-fluorouracil-resistant triple-negative breast cancer cell line.
Int. J. Oncol. 43:1985-1991(2013)

Cross-references
Other Wikidata; Q54904612
Entry history
Entry creation03-Feb-2014
Last entry update02-Jul-2020
Version number13