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Cellosaurus MDCK-MDR1 (CVCL_S586)

[Text version]

Cell line name MDCK-MDR1
Accession CVCL_S586
Resource Identification Initiative To cite this cell line use: MDCK-MDR1 (RRID:CVCL_S586)
Comments Transfected with: HGNC; 40; ABCB1.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Caution: There is another MDCK-II cell line with transfected human ABCB1: MDCK2-ABCB1 (CVCL_A2JZ).
Derived from sampling site: Kidney.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel.
Hierarchy Parent: CVCL_0424 (MDCK-II)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages http://www.creativecell.hu/cell-line_rtu_abc.html

PubMed=9426231; DOI=10.1016/S0014-5793(97)01442-7
Evers R., Cnubben N.H.P., Wijnholds J., van Deemter L., van Bladeren P.J., Borst P.
Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.
FEBS Lett. 419:112-116(1997)

PubMed=12134945; DOI=10.1023/A:1016140429238
Tang F.-X., Horie K., Borchardt R.T.
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
Pharm. Res. 19:765-772(2002)

PubMed=16749865; DOI=10.1021/mp0500768
Luo S., Kansara V.S., Zhu X., Mandava N.K., Pal D., Mitra A.K.
Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery.
Mol. Pharm. 3:329-339(2006)

PubMed=21766308; DOI=10.1002/jps.22674
Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X., Gebhard D.F., Lai Y., Federico J.J. III, Davidson R.E., Smith R., Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S., Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D.
Development of a new permeability assay using low-efflux MDCKII cells.
J. Pharm. Sci. 100:4974-4985(2011)

Ontologies BTO; BTO:0005423
Other Wikidata; Q54904783
Entry history
Entry creation03-Feb-2014
Last entry update12-Jan-2021
Version number13