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Cellosaurus CCRF-CEM/R1 (CVCL_S649)

[Text version]

Cell line name CCRF-CEM/R1
Synonyms CEM/R1; R1-CCRF-CEM
Accession CVCL_S649
Resource Identification Initiative To cite this cell line use: CCRF-CEM/R1 (RRID:CVCL_S649)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Children:
CVCL_S650 (CCRF-CEM/R2 )
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

CLPUB00028
Mini E., Medina W.D., Srimatkandada S., Moroson B.A., Bertino J.R.
Establishment and characterization of methotrexate-resistant human cell lines and effects of folate antagonists.
Clin. Res. 31:509A-509A(1983)

PubMed=3855284
Mini E., Moroson B.A., Franco C.T., Bertino J.R.
Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines.
Cancer Res. 45:325-330(1985)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL3307611
ChEMBL-Targets; CHEMBL614384
Encyclopedic resources Wikidata; Q54809034
Entry history
Entry creation03-Feb-2014
Last entry update23-Jun-2022
Version number18