ID   CCRF-CEM/R3
AC   CVCL_S651
SY   CEM/R3; CEM/MTX
DR   cancercelllines; CVCL_S651
DR   Wikidata; Q54809036
RX   CelloPub=CLPUB00028;
RX   PubMed=3855284;
RX   PubMed=6929188;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 20
//
RX   CelloPub=CLPUB00028;
RA   Mini E., Medina W.D., Srimatkandada S., Moroson B.A., Bertino J.R.;
RT   "Establishment and characterization of methotrexate-resistant human
RT   cell lines and effects of folate antagonists.";
RL   Clin. Res. 31:509A-509A(1983).
//
RX   PubMed=3855284;
RA   Mini E., Moroson B.A., Franco C.T., Bertino J.R.;
RT   "Cytotoxic effects of folate antagonists against methotrexate-resistant
RT   human leukemic lymphoblast CCRF-CEM cell lines.";
RL   Cancer Res. 45:325-330(1985).
//
RX   PubMed=6929188; DOI=10.1016/0006-2952(80)90391-3;
RA   Rosowsky A., Lazarus H., Yuan G.C., Beltz W.R., Mangini L.,
RA   Abelson H.T., Modest E.J., Frei E. III;
RT   "Effects of methotrexate esters and other lipophilic antifolates on
RT   methotrexate-resistant human leukemic lymphoblasts.";
RL   Biochem. Pharmacol. 29:648-652(1980).
//