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Cellosaurus MOLT-3/MTXt (CVCL_S652)
[Text version]
| Cell line name |
MOLT-3/MTXt
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| Accession |
CVCL_S652
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| Resource Identification Initiative |
To cite this cell line use: MOLT-3/MTXt (RRID:CVCL_S652) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
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| Sequence variations |
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
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| Disease |
Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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| Hierarchy |
Parent: CVCL_0624 (MOLT-3)
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| Sex of cell |
Male
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| Age at sampling |
19Y
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| Category |
Cancer cell line
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| Publications | PubMed=6978176
Ohnoshi T., Ohnuma T., Takahashi I., Scanlon K.J., Kamen B.A., Holland J.F.
Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
Cancer Res. 42:1655-1660(1982) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q54906356
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| Entry history |
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| Entry creation | 03-Feb-2014 |
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| Last entry update | 23-Jun-2022 |
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| Version number | 13 |
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