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Cellosaurus MOLT-3/MTX10000 (CVCL_S658)

[Text version]

Cell line name MOLT-3/MTX10000
Synonyms MOLT-3/MTX10,000
Accession CVCL_S658
Resource Identification Initiative To cite this cell line use: MOLT-3/MTX10000 (RRID:CVCL_S658)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0624 (MOLT-3)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line

Ohnuma T., Lo R.J., Scanlon K.J., Kamen B.A., Ohnoshi T., Wolman S.R., Holland J.F.
Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro.
Cancer Res. 45:1815-1822(1985)

PubMed=8608962; DOI=10.1002/(SICI)1097-0215(19960328)66:1<29::AID-IJC6>3.0.CO;2-0
Takemura Y., Kobayashi H., Gibson W., Kimbell R., Miyachi H., Jackman A.L.
The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
Int. J. Cancer 66:29-36(1996)

Encyclopedic resources Wikidata; Q54906354
Entry history
Entry creation03-Feb-2014
Last entry update23-Jun-2022
Version number13