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Cellosaurus MOLT-3/MTX200 (CVCL_S659)

[Text version]

Cell line name MOLT-3/MTX200
Accession CVCL_S659
Resource Identification Initiative To cite this cell line use: MOLT-3/MTX200 (RRID:CVCL_S659)
Comments Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from sampling site: Peripheral blood.
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0624 (MOLT-3)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=3856477
Ohnuma T., Lo R.J., Scanlon K.J., Kamen B.A., Ohnoshi T., Wolman S.R., Holland J.F.
Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro.
Cancer Res. 45:1815-1822(1985)

Cross-references
Encyclopedic resources Wikidata; Q54906355
Entry history
Entry creation03-Feb-2014
Last entry update20-May-2021
Version number12