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Cellosaurus MOLT-3/ZD1694.C (CVCL_S661)
[Text version]
| Cell line name |
MOLT-3/ZD1694.C
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| Accession |
CVCL_S661
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| Resource Identification Initiative |
To cite this cell line use: MOLT-3/ZD1694.C (RRID:CVCL_S661) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:5847; ICI D1694 (Tomudex; ZD1694).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
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| Sequence variations |
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
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| Disease |
Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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| Hierarchy |
Parent: CVCL_0624 (MOLT-3)
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| Sex of cell |
Male
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| Age at sampling |
19Y
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| Category |
Cancer cell line
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| Publications | PubMed=8576277; DOI=10.1007/BF01226268
Takemura Y., Gibson W., Kimbell R., Kobayashi H., Miyachi H., Jackman A.L.
Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug.
J. Cancer Res. Clin. Oncol. 122:109-117(1996) PubMed=8608962; DOI=10.1002/(SICI)1097-0215(19960328)66:1<29::AID-IJC6>3.0.CO;2-0
Takemura Y., Kobayashi H., Gibson W., Kimbell R., Miyachi H., Jackman A.L.
The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
Int. J. Cancer 66:29-36(1996) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q54906363
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| Entry history |
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| Entry creation | 03-Feb-2014 |
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| Last entry update | 23-Jun-2022 |
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| Version number | 13 |
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