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Cellosaurus MOLT-3/ZD1694.P9 (CVCL_S662)

[Text version]

Cell line name MOLT-3/ZD1694.P9
Accession CVCL_S662
Resource Identification Initiative To cite this cell line use: MOLT-3/ZD1694.P9 (RRID:CVCL_S662)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:5847; ICI D1694 (Tomudex; ZD1694).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0624 (MOLT-3)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line

PubMed=8608962; DOI=10.1002/(SICI)1097-0215(19960328)66:1<29::AID-IJC6>3.0.CO;2-0
Takemura Y., Kobayashi H., Gibson W., Kimbell R., Miyachi H., Jackman A.L.
The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
Int. J. Cancer 66:29-36(1996)

Encyclopedic resources Wikidata; Q54906364
Entry history
Entry creation03-Feb-2014
Last entry update23-Jun-2022
Version number13