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Cellosaurus HCC4011-GR-high (CVCL_S701)

Cell line name HCC4011-GR-high
Accession CVCL_S701
Resource Identification Initiative To cite this cell line use: HCC4011-GR-high (RRID:CVCL_S701)
Comments Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Sequence variations EGFR p.Leu858Arg (c.2573T>G) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S700 (HCC4011)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line

PubMed=23542356; DOI=10.1158/0008-5472.CAN-12-4136
Shien K., Toyooka S., Yamamoto H., Soh J., Jida M., Thu K.L., Hashida S., Maki Y., Ichihara E., Asano H., Tsukuda K., Takigawa N., Kiura K., Gazdar A.F., Lam W.L., Miyoshi S.
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
Cancer Res. 73:3051-3061(2013)

Other Wikidata; Q54881732
Polymorphism and mutation databases Cosmic; 1896433