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Cellosaurus HCC4011-GR-step (CVCL_S702)

[Text version]

Cell line name HCC4011-GR-step
Accession CVCL_S702
Resource Identification Initiative To cite this cell line use: HCC4011-GR-step (RRID:CVCL_S702)
Comments Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Sequence variations EGFR p.Leu858Arg (c.2573T>G) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S700 (HCC4011)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=23542356; DOI=10.1158/0008-5472.CAN-12-4136
Shien K., Toyooka S., Yamamoto H., Soh J., Jida M., Thu K.L., Hashida S., Maki Y., Ichihara E., Asano H., Tsukuda K., Takigawa N., Kiura K., Gazdar A.F., Lam W.L., Miyoshi S.
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
Cancer Res. 73:3051-3061(2013)

Cross-references
Other Wikidata; Q54881733
Polymorphism and mutation databases Cosmic; 1896432
Entry history
Entry creation03-Feb-2014
Last entry updated07-Sep-2018
Version number7