Cellosaurus HCC4011-GR-step (CVCL_S702)

Cell line name HCC4011-GR-step
Accession CVCL_S702
Resource Identification Initiative To cite this cell line use: HCC4011-GR-step (RRID:CVCL_S702)
Comments Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Sequence variation: EGFR p.Leu858Arg (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S700 (HCC4011)
Sex of cell Male
Category Cancer cell line

PubMed=23542356; DOI=10.1158/0008-5472.CAN-12-4136
Shien K., Toyooka S., Yamamoto H., Soh J., Jida M., Thu K.L., Hashida S., Maki Y., Ichihara E., Asano H., Tsukuda K., Takigawa N., Kiura K., Gazdar A.F., Lam W.L., Miyoshi S.
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
Cancer Res. 73:3051-3061(2013)

Polymorphism and mutation databases Cosmic; 1896432