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Cellosaurus PC-9-GR-step (CVCL_S707)

[Text version]

Cell line name PC-9-GR-step
Accession CVCL_S707
Resource Identification Initiative To cite this cell line use: PC-9-GR-step (RRID:CVCL_S707)
Comments Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Sequence variations EGFR p.Glu746_Ala750del (c.2235_2249del15) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=23542356; DOI=10.1158/0008-5472.CAN-12-4136
Shien K., Toyooka S., Yamamoto H., Soh J., Jida M., Thu K.L., Hashida S., Maki Y., Ichihara E., Asano H., Tsukuda K., Takigawa N., Kiura K., Gazdar A.F., Lam W.L., Miyoshi S.
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
Cancer Res. 73:3051-3061(2013)

Cross-references
Other Wikidata; Q54938471
Polymorphism and mutation databases Cosmic; 1896428
Entry history
Entry creation03-Feb-2014
Last entry updated06-Sep-2019
Version number10