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Cellosaurus EWS-502 (CVCL_S740)

[Text version]

Cell line name EWS-502
Synonyms EWS/502; EWS502
Accession CVCL_S740
Resource Identification Initiative To cite this cell line use: EWS-502 (RRID:CVCL_S740)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
From: Fletcher J.A.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School; Boston; USA.
Doubling time: 46 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: shRNA library screening.
Sequence variations Homozygous for TP53 p.Cys135Phe (c.404G>T) (ClinVar=VCV000376559) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North4.68
East Asian, South0
South Asian0
European, North38.28
European, South51.14
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line

PubMed=16766266; DOI=10.1016/j.ccr.2006.04.021
Davis I.J., Kim J.J., Ozsolak F., Widlund H.R., Rozenblatt-Rosen O., Granter S.R., Du J., Fletcher J.A., Denny C.T., Lessnick S.L., Linehan W.M., Kung A.L., Fisher D.E.
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.
Cancer Cell 9:473-484(2006)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=29866822; DOI=10.1073/pnas.1802079115
Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A., Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D., Bradner J.E.
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line databases/resources CCLE; EWS502_BONE
Cell_Model_Passport; SIDM01499
DepMap; ACH-000279
Biological sample resources BioSample; SAMN10988395
Chemistry resources PharmacoDB; EWS502_362_2019
Gene expression databases GEO; GSM2527268
GEO; GSM2527269
Other Wikidata; Q54833006
Polymorphism and mutation databases Cosmic; 2294584
Progenetix; CVCL_S740
Entry history
Entry creation03-Feb-2014
Last entry update29-Oct-2020
Version number14