ID   EWS-502
AC   CVCL_S740
SY   EWS/502; EWS502
DR   BioSample; SAMN10988395
DR   CCLE; EWS502_BONE
DR   Cell_Model_Passport; SIDM01499
DR   Cosmic; 2294584
DR   DepMap; ACH-000279
DR   PharmacoDB; EWS502_362_2019
DR   Wikidata; Q54833006
RX   PubMed=16766266;
RX   PubMed=25984343;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   From: Fletcher J.A.; Department of Pathology, Brigham and Women's Hospital; Harvard Medical School; Boston; USA.
CC   Doubling time: 46 hours (PubMed=25984343).
CC   Sequence variation: Homozygous for TP53 p.Cys135Phe (c.404G>T) (CCLE).
CC   Omics: Deep exome analysis.
CC   Omics: shRNA library screening.
CC   Genome ancestry: African=5.9%; Native American=0%; East Asian, North=4.68%; East Asian, South=0%; South Asian=0%; European, North=38.28%; European, South=51.14% (PubMed=30894373).
DI   NCIt; C4817; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 06-09-19; Version: 11
//
RX   PubMed=16766266; DOI=10.1016/j.ccr.2006.04.021;
RA   Davis I.J., Kim J.J., Ozsolak F., Widlund H.R., Rozenblatt-Rosen O.,
RA   Granter S.R., Du J., Fletcher J.A., Denny C.T., Lessnick S.L.,
RA   Linehan W.M., Kung A.L., Fisher D.E.;
RT   "Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT
RT   family of human cancers.";
RL   Cancer Cell 9:473-484(2006).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//