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Cellosaurus 11-18/R (CVCL_S745)

[Text version]
Cell line name 11-18/R
Synonyms 11-18R; 11-18/ER
Accession CVCL_S745
Resource Identification Initiative To cite this cell line use: 11-18/R (RRID:CVCL_S745)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=22773810).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6659 (11-18)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=22773810; DOI=10.1073/pnas.1203530109
Ohashi K., Sequist L.V., Arcila M.E., Moran T., Chmielecki J., Lin Y.-L., Pan Y.-M., Wang L., de Stanchina E., Shien K., Aoe K., Toyooka S., Kiura K., Fernandez-Cuesta L., Fidias P., Yang J.C.-H., Miller V.A., Riely G.J., Kris M.G., Engelman J.A., Vnencak-Jones C.L., Dias-Santagata D., Ladanyi M., Pao W.
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S745
Encyclopedic resources Wikidata; Q54554912
Polymorphism and mutation databases Cosmic; 1890459
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number14