ID   HCC4006/R
AC   CVCL_S746
SY   HCC4006R; HCC4006/ER; HCC4006ER
DR   cancercelllines; CVCL_S746
DR   Cosmic; 1890457
DR   Cosmic; 2015232
DR   Wikidata; Q54881727
RX   PubMed=22773810;
RX   PubMed=23733853;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Leu747_Glu749del (c.2239_2247delTAAGAGAA); ClinVar=VCV000177765; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr205His (c.613T>C); ClinVar=VCV000376685; Zygosity=Homozygous (from parent cell line).
CC   Omics: Deep exome analysis.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1269 ! HCC4006
SX   Male
AG   >50Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 16
//
RX   PubMed=22773810; DOI=10.1073/pnas.1203530109;
RA   Ohashi K., Sequist L.V., Arcila M.E., Moran T., Chmielecki J.,
RA   Lin Y.-L., Pan Y.-M., Wang L., de Stanchina E., Shien K., Aoe K.,
RA   Toyooka S., Kiura K., Fernandez-Cuesta L., Fidias P., Yang J.C.-H.,
RA   Miller V.A., Riely G.J., Kris M.G., Engelman J.A., Vnencak-Jones C.L.,
RA   Dias-Santagata D., Ladanyi M., Pao W.;
RT   "Lung cancers with acquired resistance to EGFR inhibitors occasionally
RT   harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or
RT   MEK1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012).
//
RX   PubMed=23733853; DOI=10.1101/gr.152322.112;
RA   Jia P.-L., Jin H.-L., Meador C.B., Xia J.-F., Ohashi K., Liu L.,
RA   Pirazzoli V., Dahlman K.B., Politi K., Michor F., Zhao Z.-M., Pao W.;
RT   "Next-generation sequencing of paired tyrosine kinase
RT   inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines
RT   identifies spectrum of DNA changes associated with drug resistance.";
RL   Genome Res. 23:1434-1445(2013).
//