Cellosaurus HCC4011/R (CVCL_S747)

Cell line name HCC4011/R
Synonyms HCC4011/ER; HCC4011R
Accession CVCL_S747
Resource Identification Initiative To cite this cell line use: HCC4011/R (RRID:CVCL_S747)
Comments Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Sequence variation: EGFR p.Leu858Arg (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S700 (HCC4011)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=22773810; DOI=10.1073/pnas.1203530109
Ohashi K., Sequist L.V., Arcila M.E., Moran T., Chmielecki J., Lin Y.-L., Pan Y., Wang L., de Stanchina E., Shien K., Aoe K., Toyooka S., Kiura K., Fernandez-Cuesta L., Fidias P., Yang J.C.-H., Miller V.A., Riely G.J., Kris M.G., Engelman J.A., Vnencak-Jones C.L., Dias-Santagata D., Ladanyi M., Pao W.
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012)

Cross-references
Polymorphism and mutation databases Cosmic; 1890458