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Cellosaurus HROC87 T0 M2 (CVCL_S854)

[Text version]
Cell line name HROC87 T0 M2
Synonyms HROC87; HROC87X
Accession CVCL_S854
Resource Identification Initiative To cite this cell line use: HROC87 T0 M2 (RRID:CVCL_S854)
Comments From: Linnebacher M.; University of Rostock; Rostock; Germany.
Population: Caucasian.
Characteristics: Established from a patient-derived xenograft established in female NMRI nu/nu mice.
Doubling time: 26 hours (CLS=300831).
Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23300683).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): CLS; Direct_author_submission; PubMed=25926053

Markers:
AmelogeninX
CSF1PO12
D5S8189,11
D7S8209
D13S31710 (Direct_author_submission)
10,14 (CLS; PubMed=25926053)
D16S53911,13
D21S1128,29
TH018
TPOX11,13
vWA16,20

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Publications

PubMed=23300683; DOI=10.1371/journal.pone.0052485
Maletzki C., Stier S., Gruenert U., Gock M., Ostwald C., Prall F., Linnebacher M.
Establishment, characterization and chemosensitivity of three mismatch repair deficient cell lines from sporadic and inherited colorectal carcinomas.
PLoS ONE 7:E52485-E52485(2012)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=31601052; DOI=10.3390/cancers11101520
Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F., Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references
Cell line collections (Providers) CLS; 300831
Cell line databases/resources cancercelllines; CVCL_S854
Encyclopedic resources Wikidata; Q54895306
Gene expression databases GEO; GSM1448072
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number22