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Cellosaurus SEMK2 (CVCL_S906)

[Text version]
Cell line name SEMK2
Synonyms SEM-K2
Accession CVCL_S906
Resource Identification Initiative To cite this cell line use: SEMK2 (RRID:CVCL_S906)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Omics: Deep exome analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 7135; AFF1 + HGNC; 7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (DepMap).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342)
B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0095 (SEM)
Children:
CVCL_S907 (SEMK2-M1)
Sex of cell Female
Age at sampling 5Y
Category Cancer cell line
Publications

PubMed=7669664; DOI=10.1111/j.1365-2141.1995.tb05207.x
Pocock C.F.E., Malone M., Booth M., Evans M., Morgan G., Greil J., Cotter F.E.
BCL-2 expression by leukaemic blasts in a SCID mouse model of biphenotypic leukaemia associated with the t(4;11)(q21;q23) translocation.
Br. J. Haematol. 90:855-867(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S906
Cell_Model_Passport; SIDM01627
DepMap; ACH-001735
Encyclopedic resources Wikidata; Q54952797
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number18