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Cellosaurus SEMK2-M1 (CVCL_S907)

[Text version]
Cell line name SEMK2-M1
Accession CVCL_S907
Resource Identification Initiative To cite this cell line use: SEMK2-M1 (RRID:CVCL_S907)
Comments Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 7135; AFF1 + HGNC; 7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342)
B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S906 (SEMK2)
Sex of cell Female
Age at sampling 5Y
Category Cancer cell line
Publications

PubMed=12620411; DOI=10.1016/S1535-6108(03)00003-5
Armstrong S.A., Kung A.L.-J., Mabon M.E., Silverman L.B., Stam R.W., Den Boer M.L., Pieters R., Kersey J.H., Sallan S.E., Fletcher J.A., Golub T.R., Griffin J.D., Korsmeyer S.J.
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.
Cancer Cell 3:173-183(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S907
Encyclopedic resources Wikidata; Q54952798
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number18