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Cellosaurus C170 (CVCL_S959)

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Cell line name C170
Accession CVCL_S959
Resource Identification Initiative To cite this cell line use: C170 (RRID:CVCL_S959)
Comments Doubling time: 26 +- 0.5 hours (PubMed=3947514).
Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Colorectal adenocarcinoma (NCIt: C5105)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25877200; PubMed=25926053

Penta D9,14
Penta E7,14

Run an STR similarity search on this cell line

PubMed=3947514; DOI=10.1038/bjc.1986.6
Durrant L.G., Robins R.A., Pimm M.V., Perkins A.C., Armitage N.C., Hardcastle J.D., Baldwin R.W.
Antigenicity of newly established colorectal carcinoma cell lines.
Br. J. Cancer 53:37-45(1986)

PubMed=3435698; DOI=10.1038/bjc.1987.277
Durrant L.G., Garnett M.C., Gallego J., Armitage N.C., Ballantyne K.C., Marksman R.A., Hardcastle J.D., Baldwin R.W.
Sensitivity of newly established colorectal cell lines to cytotoxic drugs and monoclonal antibody drug conjugates.
Br. J. Cancer 56:722-726(1987)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

Cell line databases/resources ColonAtlas; C170
Ontologies EFO; EFO_0006363
Biological sample resources BioSample; SAMN03473189
Chemistry resources ChEMBL-Cells; CHEMBL3308628
ChEMBL-Targets; CHEMBL614705
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM206448
GEO; GSM274834
GEO; GSM513927
GEO; GSM514181
GEO; GSM827320
GEO; GSM1448107
Other Wikidata; Q54807871