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Cellosaurus HSC-GRW (CVCL_S965)

[Text version]
Cell line name HSC-GRW
Accession CVCL_S965
Resource Identification Initiative To cite this cell line use: HSC-GRW (RRID:CVCL_S965)
Comments Characteristics: KITLG dependent.
Sequence variations
  • Mutation; HGNC; 4170; GATA1; Simple; p.Pro50fs*6 (c.150_184del35); Zygosity=Unspecified (PubMed=12586620).
Disease Down syndrome (NCIt: C2993)
Myeloid leukemia associated with Down syndrome (NCIt: C43223)
Down syndrome (ORDO: Orphanet_870)
Acute megakaryoblastic leukemia in Down syndrome (ORDO: Orphanet_99887)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

CLPUB00052
Zipursky A., Vanek W., Grunberger T., Brown E.J., Wang H., Sutherland D.R., Yeo E., Cohen A., Christensen H., Freedman M.H.
A megakaryoblast cell line from a patient with Down syndrome-acute megakaryoblastic leukemia (DS-AMKL): in vitro differentiation of megakaryoblasts.
Blood 82 Suppl. 1:122a-122a(1993)

PubMed=12586620; DOI=10.1182/blood-2003-01-0013
Hitzler J.K., Cheung J., Li Y., Scherer S.W., Zipursky A.
GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome.
Blood 101:4301-4304(2003)

Cross-references
Encyclopedic resources Wikidata; Q54896415
Polymorphism and mutation databases Cosmic; 977943
Entry history
Entry creation03-Feb-2014
Last entry update21-Mar-2023
Version number9