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Cellosaurus GIST-T1/829 (CVCL_S983)

[Text version]
Cell line name GIST-T1/829
Accession CVCL_S983
Resource Identification Initiative To cite this cell line use: GIST-T1/829 (RRID:CVCL_S983)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; 6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (PubMed=22665524).
  • Mutation; HGNC; 6342; KIT; Simple; p.Ala829Pro (c.2485G>C); ClinVar=VCV000375933; Zygosity=Heterozygous (PubMed=22665524).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4976 (GIST-T1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=22665524; DOI=10.1158/1535-7163.MCT-12-0223
Heinrich M.C., Marino-Enriquez A., Presnell A., Donsky R.S., Griffith D.J., McKinley A., Patterson J., Taguchi T., Liang C.-W., Fletcher J.A.
Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors.
Mol. Cancer Ther. 11:1770-1780(2012)

PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397
Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A.B., Zhou T.-J., Serrano C., Eilers G., Zhu M.-J., Ketzer J., Wardwell S., Ning Y., Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C., Fletcher J.A., Bauer S., Rivera V.M.
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Clin. Cancer Res. 20:5745-5755(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S983
Encyclopedic resources Wikidata; Q54835853
Polymorphism and mutation databases Cosmic; 1873952
Entry history
Entry creation03-Feb-2014
Last entry update30-Jan-2024
Version number15