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Cellosaurus FaDu-R (CVCL_SA75)

[Text version]
Cell line name FaDu-R
Accession CVCL_SA75
Resource Identification Initiative To cite this cell line use: FaDu-R (RRID:CVCL_SA75)
Comments Population: Indian.
Characteristics: Established from parent cell line after a cumulative irradiation dose of 90 Gy.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (from parent cell line).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1218 (FaDu)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=28844650; DOI=10.1016/j.anl.2017.07.011
Cho K.-J., Park E.-J., Kim M.-S., Joo Y.-H.
Characterization of FaDu-R, a radioresistant head and neck cancer cell line, and cancer stem cells.
Auris Nasus Larynx 45:566-573(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_SA75
Encyclopedic resources Wikidata; Q54833222
Entry history
Entry creation14-May-2018
Last entry update05-Oct-2023
Version number12