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Cellosaurus PC-9/BR (CVCL_T015)

[Text version]

Cell line name PC-9/BR
Synonyms PC-9BR; PC-9/BRc1; PC-9BRc1
Accession CVCL_T015
Resource Identification Initiative To cite this cell line use: PC-9/BR (RRID:CVCL_T015)
Comments Selected for resistance to: ChEBI; CHEBI:61390; Afatinib (BIBW-2992).
Omics: Deep RNAseq analysis.
Sequence variations EGFR p.Glu746_Ala750del (c.2235_2249del15) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line

PubMed=21734175; DOI=10.1126/scitranslmed.3002356
Chmielecki J., Foo J., Oxnard G.R., Hutchinson K., Ohashi K., Somwar R., Wang L., Amato K.R., Arcila M.E., Sos M.L., Socci N.D., Viale A.J., de Stanchina E., Ginsberg M.S., Thomas R.K., Kris M.G., Inoue A., Ladanyi M., Miller V.A., Michor F., Pao W.
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.
Sci. Transl. Med. 3:90ra59-90ra59(2011)

PubMed=23733853; DOI=10.1101/gr.152322.112
Jia P., Jin H., Meador C.B., Xia J., Ohashi K., Liu L., Pirazzoli V., Dahlman K.B., Politi K., Michor F., Zhao Z., Pao W.
Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.
Genome Res. 23:1434-1445(2013)

Other Wikidata; Q54938480
Polymorphism and mutation databases Cosmic; 2015227
Entry history
Entry creation03-Feb-2014
Last entry updated06-Sep-2019
Version number11