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Cellosaurus U266/velR (CVCL_T031)

[Text version]

Cell line name U266/velR
Accession CVCL_T031
Resource Identification Initiative To cite this cell line use: U266/velR (RRID:CVCL_T031)
Comments Characteristics: Produces IgE lambda.
Selected for resistance to: ChEBI; CHEBI:52717; Bortezomib (Velcade).
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for BRAF p.Lys601Asn (c.1803A>T) (from parent cell line).
Heterozygous for MSH6 p.Gly141Asp (c.422G>A) (from parent cell line).
Homozygous for TP53 p.Ala161Thr (c.481G>A) (ClinVar=VCV000161518) (from parent cell line).
Homozygous for TRAF3 p.Lys550Leufs*3 (c.1648_1649insT) (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=24286313; DOI=10.5483/bmbrep.2014.47.5.134
Park J., Choi J.-H., Bae E.-K., Lee C., Jung W.J., Ahn K.-S., Yoon S.-S.
Establishment and characterization of bortezomib-resistant U266 cell line: constitutive activation of NF-kappaB-mediated cell signals and/or alterations of ubiquitylation-related genes reduce bortezomib-induced apoptosis.
BMB Rep. 47:274-279(2013)

Cross-references
Other Wikidata; Q54973633
Entry history
Entry creation03-Feb-2014
Last entry update02-Jul-2020
Version number10