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Cellosaurus U266/velR (CVCL_T031)

[Text version]
Cell line name U266/velR
Accession CVCL_T031
Resource Identification Initiative To cite this cell line use: U266/velR (RRID:CVCL_T031)
Comments Population: Caucasian.
Characteristics: Produces IgE lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:52717; Bortezomib (Velcade).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=24286313; DOI=10.5483/BMBRep.2014.47.5.134
Park J., Bae E.-K., Lee C., Choi J.-H., Jung W.J., Ahn K.-S., Yoon S.-S.
Establishment and characterization of bortezomib-resistant U266 cell line: constitutive activation of NF-kappaB-mediated cell signals and/or alterations of ubiquitylation-related genes reduce bortezomib-induced apoptosis.
BMB Rep. 47:274-279(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_T031
Encyclopedic resources Wikidata; Q54973633
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number16