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Cellosaurus U-2 OS R1 (CVCL_T429)

[Text version]
Cell line name U-2 OS R1
Accession CVCL_T429
Resource Identification Initiative To cite this cell line use: U-2 OS R1 (RRID:CVCL_T429)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Children:
CVCL_T430 (U-2 OS R2)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=17096323; DOI=10.1002/ijc.22327
Lourda M., Trougakos I.P., Gonos E.S.
Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of clusterin/apolipoprotein J.
Int. J. Cancer 120:611-622(2007)

Cross-references
Encyclopedic resources Wikidata; Q54973538
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number11