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Cellosaurus KH OS R1 (CVCL_T431)

[Text version]
Cell line name KH OS R1
Accession CVCL_T431
Resource Identification Initiative To cite this cell line use: KH OS R1 (RRID:CVCL_T431)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Transformant: NCBI_TaxID; 11808; Kirsten murine sarcoma virus (Ki-MSV).
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2546 (KHOS/NP)
Children:
CVCL_T432 (KH OS R2)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
Publications

PubMed=17096323; DOI=10.1002/ijc.22327
Lourda M., Trougakos I.P., Gonos E.S.
Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of clusterin/apolipoprotein J.
Int. J. Cancer 120:611-622(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_T431
Encyclopedic resources Wikidata; Q54899846
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number15