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Cellosaurus KH OS R2 (CVCL_T432)

[Text version]
Cell line name KH OS R2
Synonyms KHOSR2; KHOS(R2); KHOS R2; KHOSMR
Accession CVCL_T432
Resource Identification Initiative To cite this cell line use: KH OS R2 (RRID:CVCL_T432)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Transformant: NCBI_TaxID; 11808; Kirsten murine sarcoma virus (Ki-MSV).
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_T431 (KH OS R1)
Children:
CVCL_T433 (KH OS R3)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
Publications

PubMed=17096323; DOI=10.1002/ijc.22327
Lourda M., Trougakos I.P., Gonos E.S.
Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of clusterin/apolipoprotein J.
Int. J. Cancer 120:611-622(2007)

PubMed=19638450; DOI=10.1158/1535-7163.MCT-09-0115
Duan Z.-F., Choy E., Harmon D., Yang C., Ryu K., Schwab J.H., Mankin H.J., Hornicek F.J.
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.
Mol. Cancer Ther. 8:2122-2130(2009)

PubMed=24866169; DOI=10.1158/2326-6066.CIR-13-0224
Shen J.K., Cote G.M., Choy E., Yang P., Harmon D., Schwab J.H., Nielsen G.P., Chebib I., Ferrone S., Wang X.-H., Wang Y.-Y., Mankin H.J., Hornicek F.J., Duan Z.-F.
Programmed cell death ligand 1 expression in osteosarcoma.
Cancer Immunol. Res. 2:690-698(2014)

PubMed=25236161; DOI=10.1186/1471-2407-14-681
Duan Z.-F., Zhang J.-M., Ye S.-N., Shen J.K., Choy E., Cote G.M., Harmon D., Mankin H.J., Hua Y.-Q., Zhang Y., Gray N.S., Hornicek F.J.
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
BMC Cancer 14:681.1-681.11(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_T432
Encyclopedic resources Wikidata; Q54899847
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number15