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Cellosaurus PB2 (CVCL_T882)

[Text version]
Cell line name PB2
Synonyms iPS_PB2
Accession CVCL_T882
Resource Identification Initiative To cite this cell line use: PB2 (RRID:CVCL_T882)
Comments Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 8607; PRKN; Unexplicit; Ex6-7del; Zygosity=Homozygous (PubMed=23039195).
Disease Parkinson disease 2, autosomal recessive juvenile (NCIt: C198603)
Young-onset Parkinson disease (ORDO: Orphanet_2828)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_ZX89 (PB(DF))
Sex of cell Male
Age at sampling 50Y
Category Induced pluripotent stem cell
Publications

PubMed=23039195; DOI=10.1186/1756-6606-5-35
Imaizumi Y., Okada Y., Akamatsu W., Koike M., Kuzumaki N., Hayakawa H., Nihira T., Kobayashi T., Ohyama M., Sato S., Takanashi M., Funayama M., Hirayama A., Soga T., Hishiki T., Suematsu M., Yagi T., Ito D., Kosakai A., Hayashi K., Shouji M., Nakanishi A., Suzuki N., Mizuno Y., Mizushima N., Amagai M., Uchiyama Y., Mochizuki H., Hattori N., Okano H.
Mitochondrial dysfunction associated with increased oxidative stress and alpha-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.
Mol. Brain 5:35.1-35.13(2012)

PubMed=26905201; DOI=10.1016/j.stemcr.2016.01.010
Matsumoto T., Fujimori K., Andoh-Noda T., Ando T., Kuzumaki N., Toyoshima M., Tada H., Imaizumi K., Ishikawa M., Yamaguchi R., Isoda M., Zhou Z., Sato S., Kobayashi T., Ohtaka M., Nishimura K., Kurosawa H., Yoshikawa T., Takahashi T., Nakanishi M., Ohyama M., Hattori N., Akamatsu W., Okano H.
Functional neurons generated from T cell-derived induced pluripotent stem cells for neurological disease modeling.
Stem Cell Reports 6:422-435(2016)

Cross-references
Cell line databases/resources SKIP; SKIP000203
Encyclopedic resources Wikidata; Q54086283
Gene expression databases GEO; GSM2038549
Entry history
Entry creation03-Feb-2014
Last entry update29-Jun-2023
Version number11