| Cell line name |
NB4-LR2 |
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| Synonyms |
NB4-R2 |
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| Accession |
CVCL_U081 |
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| Resource Identification Initiative |
To cite this cell line use: NB4-LR2 (RRID:CVCL_U081) |
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| Comments |
Population: Caucasian.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. |
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| Sequence variations |
- Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
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| Disease |
Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_8811 (NB4-LR1) |
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| Sex of cell |
Female |
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| Age at sampling |
23Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=7915840; DOI=10.1073/pnas.91.18.8428
Ruchaud S., Duprez E., Gendron M.C., Houge G., Genieser H.-G., Jastorff B., Doskeland S.O., Lanotte M.
Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.
Proc. Natl. Acad. Sci. U.S.A. 91:8428-8432(1994) PubMed=10673742; DOI=10.1038/sj.leu.2401683
Duprez E., Benoit G., Flexor M., Lillehaug J.R., Lanotte M.
A mutated PML/RARA found in the retinoid maturation resistant NB4 subclone, NB4-R2, blocks RARA and wild-type PML/RARA transcriptional activities.
Leukemia 14:255-261(2000) PubMed=11704857; DOI=10.1038/sj.onc.1204863
Roussel M.J.S., Lanotte M.
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_U081
|
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| Anatomy/cell type resources |
BTO; BTO:0006044
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| Encyclopedic resources |
Wikidata; Q54907533
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| Entry history |
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| Entry creation | 03-Feb-2014 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 17 |
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