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Cellosaurus NB4/As (CVCL_U082)

[Text version]

Cell line name NB4/As
Synonyms NB4-N-AsR1
Accession CVCL_U082
Resource Identification Initiative To cite this cell line use: NB4/As (RRID:CVCL_U082)
Comments Selected for resistance to: ChEBI; CHEBI:30621; Diarsenic trioxide (ATO; As2O3).
Derived from sampling site: Bone marrow.
Sequence variations PML-RARA gene fusion (from parent cell line).
Heterozygous for KRAS p.Ala18Asp (c.53C>A) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line

PubMed=11021749; DOI=10.1038/sj.leu.2401900
Kitamura K., Minami Y., Yamamoto K., Akao Y., Kiyoi H., Saito H., Naoe T.
Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis.
Leukemia 14:1743-1750(2000)

PubMed=11704857; DOI=10.1038/sj.onc.1204863
Roussel M.J., Lanotte M.
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001)

Other Wikidata; Q54907535
Entry history
Entry creation03-Feb-2014
Last entry update02-Jul-2020
Version number12