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Cellosaurus NB4.007/6 (CVCL_U083)

[Text version]

Cell line name NB4.007/6
Synonyms NB4-007/6; NB4-GR007/6
Accession CVCL_U083
Resource Identification Initiative To cite this cell line use: NB4.007/6 (RRID:CVCL_U083)
Comments Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from sampling site: Bone marrow.
Sequence variations Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (PubMed=12353268).
Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line

PubMed=7719237; DOI=10.3109/10428199509049768
Dermime S., Grignani F., Rogaia D., Liberatore C., Marchesi E., Gambacorti-Passerini C.
Acute promyelocytic leukaemia cells resistant to retinoic acid show further perturbation of the RAR alpha signal transduction system.
Leuk. Lymphoma 16:289-295(1995)

PubMed=11704857; DOI=10.1038/sj.onc.1204863
Roussel M.J., Lanotte M.
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001)

PubMed=12353268; DOI=10.1002/gcc.10117
Mozziconacci M.-J., Rosenauer A., Restouin A., Fanelli M., Shao W.-L., Fernandez F., Toiron Y., Viscardi J., Gambacorti-Passerini C., Miller W.H. Jr., Lafage-Pochitaloff M.
Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones.
Genes Chromosomes Cancer 35:261-270(2002)

Other Wikidata; Q54907536
Entry history
Entry creation03-Feb-2014
Last entry update20-May-2021
Version number14