ID   NB4.007/6
AC   CVCL_U083
SY   NB4-007/6; NB4-GR007/6
DR   cancercelllines; CVCL_U083
DR   Wikidata; Q54907536
RX   PubMed=7719237;
RX   PubMed=11704857;
RX   PubMed=12353268;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
CC   Sequence variation: Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (PubMed=12353268).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0005 ! NB4
SX   Female
AG   23Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 17
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RX   PubMed=7719237; DOI=10.3109/10428199509049768;
RA   Dermime S., Grignani F., Rogaia D., Liberatore C., Marchesi E.,
RA   Gambacorti-Passerini C.;
RT   "Acute promyelocytic leukaemia cells resistant to retinoic acid show
RT   further perturbation of the RAR alpha signal transduction system.";
RL   Leuk. Lymphoma 16:289-295(1995).
//
RX   PubMed=11704857; DOI=10.1038/sj.onc.1204863;
RA   Roussel M.J.S., Lanotte M.;
RT   "Maturation sensitive and resistant t(15;17) NB4 cell lines as tools
RT   for APL physiopathology: nomenclature of cells and repertory of their
RT   known genetic alterations and phenotypes.";
RL   Oncogene 20:7287-7291(2001).
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RX   PubMed=12353268; DOI=10.1002/gcc.10117;
RA   Mozziconacci M.-J., Rosenauer A., Restouin A., Fanelli M., Shao W.-L.,
RA   Fernandez F., Toiron Y., Viscardi J., Gambacorti-Passerini C.,
RA   Miller W.H. Jr., Lafage-Pochitaloff M.;
RT   "Molecular cytogenetics of the acute promyelocytic leukemia-derived
RT   cell line NB4 and of four all-trans retinoic acid-resistant
RT   subclones.";
RL   Genes Chromosomes Cancer 35:261-270(2002).
//