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Cellosaurus NB4-DR3 (CVCL_U088)

[Text version]
Cell line name NB4-DR3
Synonyms NB4-R3
Accession CVCL_U088
Resource Identification Initiative To cite this cell line use: NB4-DR3 (RRID:CVCL_U088)
Comments Population: Caucasian.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U086 (NB4-S1)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
Publications

PubMed=9342843; DOI=10.1046/j.1432-0436.1997.6150321.x
Nason-Burchenal K., Maerz W., Albanell J., Allopenna J., Martin P., Moore M.A.S., Dmitrovsky E.
Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization.
Differentiation 61:321-331(1997)

PubMed=11704857; DOI=10.1038/sj.onc.1204863
Roussel M.J.S., Lanotte M.
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_U088
Encyclopedic resources Wikidata; Q54907531
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number17