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Cellosaurus NB4.437r (CVCL_U112)

[Text version]

Cell line name NB4.437r
Synonyms NB4-437r; NB4-G-437R
Accession CVCL_U112
Resource Identification Initiative To cite this cell line use: NB4.437r (RRID:CVCL_U112)
Comments Selected for resistance to: ChEBI; CHEBI:88334; AHPN (6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalenecarboxylic acid; CD437).
Derived from sampling site: Bone marrow.
Sequence variations Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line

PubMed=10753850; DOI=10.1182/blood.V95.8.2672
Ponzanelli I., Gianni M., Giavazzi R., Garofalo A., Nicoletti I., Reichert U., Erba E., Rambaldi A., Terao M., Garattini E.
Isolation and characterization of an acute promyelocytic leukemia cell line selectively resistant to the novel antileukemic and apoptogenic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid.
Blood 95:2672-2682(2000)

PubMed=11704857; DOI=10.1038/sj.onc.1204863
Roussel M.J., Lanotte M.
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
Oncogene 20:7287-7291(2001)

Other Wikidata; Q54907538
Entry history
Entry creation03-Feb-2014
Last entry update20-May-2021
Version number15