ID   NB4.437r
AC   CVCL_U112
SY   NB4-437r; NB4-G-437R
DR   cancercelllines; CVCL_U112
DR   Wikidata; Q54907538
RX   PubMed=10753850;
RX   PubMed=11704857;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:88334; AHPN (6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalenecarboxylic acid; CD437).
CC   Sequence variation: Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0005 ! NB4
SX   Female
AG   23Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 18
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RX   PubMed=10753850; DOI=10.1182/blood.V95.8.2672;
RA   Ponzanelli I., Gianni M., Giavazzi R., Garofalo A., Nicoletti I.,
RA   Reichert U., Erba E., Rambaldi A., Terao M., Garattini E.;
RT   "Isolation and characterization of an acute promyelocytic leukemia
RT   cell line selectively resistant to the novel antileukemic and
RT   apoptogenic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene
RT   carboxylic acid.";
RL   Blood 95:2672-2682(2000).
//
RX   PubMed=11704857; DOI=10.1038/sj.onc.1204863;
RA   Roussel M.J.S., Lanotte M.;
RT   "Maturation sensitive and resistant t(15;17) NB4 cell lines as tools
RT   for APL physiopathology: nomenclature of cells and repertory of their
RT   known genetic alterations and phenotypes.";
RL   Oncogene 20:7287-7291(2001).
//