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Cellosaurus MR1-3 (CVCL_U180)

[Text version]
Cell line name MR1-3
Accession CVCL_U180
Resource Identification Initiative To cite this cell line use: MR1-3 (RRID:CVCL_U180)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U209 (HeLa S3 mer-)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): PubMed=25877200; RCB

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135815,18
D5S81811,12
D7S8208
D8S117912
D13S31713.3
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
FGA21
Penta D8,15
Penta E7,16,17
TH017
TPOX8,12
vWA15,18

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Publications

PubMed=3608093; DOI=10.1093/carcin/8.8.1109
Ishida R., Takahashi T.
N-methyl-N'-nitro-N-nitrosoguanidine-resistant HeLa S3 cells still have little O6-methylguanine-DNA methyltransferase activity and are hypermutable by alkylating agents.
Carcinogenesis 8:1109-1113(1987)

PubMed=2372878; DOI=10.1093/carcin/11.7.1209
Ishida R., Utsumi K.R.
Differences in induction of sister chromatid exchanges in MNNG-resistant HeLa S3 Mer- cell lines.
Carcinogenesis 11:1209-1212(1990)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) RCB; RCB0504
Cell line databases/resources CLO; CLO_0050915
Biological sample resources BioSample; SAMN03470994
Encyclopedic resources Wikidata; Q54906568
Polymorphism and mutation databases Cosmic; 753593
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number15