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Cellosaurus CEM/A7 (CVCL_U261)

[Text version]

Cell line name CEM/A7
Synonyms CEM-A7
Accession CVCL_U261
Resource Identification Initiative To cite this cell line use: CEM/A7 (RRID:CVCL_U261)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=7903222; DOI=10.1007/BF00685329
Zalcberg J.R., Hu X.F., Ching M., Wakeling A.E., Wall D.M., Marschner I.C., de Luise M.
Differential effects of estrogen, tamoxifen and the pure antiestrogen ICI 182,780 in human drug-resistant leukemia cell lines.
Cancer Chemother. Pharmacol. 33:123-129(1993)

PubMed=7514153; DOI=10.1002/ijc.2910570414
Zalcberg J.R., Hu X.F., Wall D.M., Mirski S.E.L., Cole S.P.C., Nadalin G., de Luise M., Parkin J.D., Vrazas V., Campbell L., Kantharidis P.
Cellular and karyotypic characterization of two doxorubicin resistant cell lines isolated from the same parental human leukemia cell line.
Int. J. Cancer 57:522-528(1994)

Cross-references
Encyclopedic resources Wikidata; Q54809267
Entry history
Entry creation03-Feb-2014
Last entry update23-Jun-2022
Version number16