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Cellosaurus 6T-CEM20 (CVCL_U293)

[Text version]

Cell line name 6T-CEM20
Synonyms 6T-CEM-20; 6-T CEM-20; 6TCEM20
Accession CVCL_U293
Resource Identification Initiative To cite this cell line use: 6T-CEM20 (RRID:CVCL_U293)
Comments Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Derived from sampling site: Peripheral blood.
Sequence variations NKX2.5-BCL11B gene fusion (from parent cell line).
Heterozygous for FBXW7 p.Arg465Cys (c.1393C>T) (from parent cell line).
Heterozygous for FLT3 p.Ala627Thr (c.1879G>A) (from parent cell line).
Heterozygous for KRAS p.Gly12Asp (c.35G>A) (from parent cell line).
Heterozygous for NOTCH1 p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36) and p.Pro2412Thr (c.7234C>A) (from parent cell line).
Heterozygous for TP53 p.Arg175His (c.524G>A) and p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6869 (6T-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=6234996; DOI=10.1016/0008-8749(84)90128-X
Lau C.Y., Budz-Tymkewycz S., Wang E.Y., Ishaque A.
A mutant human T-cell line producing immunosuppressive factor(s).
Cell. Immunol. 87:35-52(1984)

Patent=US4705687
Lau C.Y.
Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor.
Patent number US4705687, 10-Nov-1987

Patent=US4728614
Lau C.Y.
Mutant human T cell line producing immunosuppressive factor and method for obtaining such mutants.
Patent number US4728614, 01-Mar-1988

Cross-references
Cell line collections ATCC; CRL-8295 - Discontinued
Other Wikidata; Q54604614
Entry history
Entry creation03-Feb-2014
Last entry updated12-Mar-2020
Version number11