ID   6T-CEM20
AC   CVCL_U293
SY   6T-CEM-20; 6-T CEM-20; 6TCEM20
DR   Wikidata; Q54604614
RX   Patent=US4705687;
RX   Patent=US4728614;
RX   PubMed=6234996;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8295.
CC   Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from sampling site: Peripheral blood.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_6869 ! 6T-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 23-09-21; Version: 16
//
RX   Patent=US4705687;
RA   Lau C.Y.;
RT   "Treatment of autoimmune diseases such as rheumatoid arthritis with
RT   suppressor factor.";
RL   Patent number US4705687, 10-Nov-1987.
//
RX   Patent=US4728614;
RA   Lau C.Y.;
RT   "Mutant human T cell line producing immunosuppressive factor and
RT   method for obtaining such mutants.";
RL   Patent number US4728614, 01-Mar-1988.
//
RX   PubMed=6234996; DOI=10.1016/0008-8749(84)90128-X;
RA   Lau C.Y., Budz-Tymkewycz S., Wang E.Y., Ishaque A.;
RT   "A mutant human T-cell line producing immunosuppressive factor(s).";
RL   Cell. Immunol. 87:35-52(1984).
//