ID   CHO 25-RA
AC   CVCL_U429
SY   25-RA; 25RA; Clone 25-RA; 25 RA CHO
DR   Wikidata; Q54812550
RX   PubMed=2404988;
RX   PubMed=3335499;
RX   PubMed=6105157;
RX   PubMed=8898195;
CC   Sequence variation: Mutation; UniProtKB; P97260; Scap; Simple; p.Asp443Asn (c.1327G>A); Zygosity=Heterozygous (PubMed=8898195).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_0214 ! CHO-K1
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 03-02-14; Last updated: 30-01-24; Version: 10
//
RX   PubMed=2404988; DOI=10.1083/jcb.110.2.295;
RA   Cadigan K.M., Spillane D.M., Chang T.-Y.;
RT   "Isolation and characterization of Chinese hamster ovary cell mutants
RT   defective in intracellular low density lipoprotein-cholesterol
RT   trafficking.";
RL   J. Cell Biol. 110:295-308(1990).
//
RX   PubMed=3335499; DOI=10.1016/S0021-9258(19)57389-6;
RA   Cadigan K.M., Heider J.G., Chang T.-Y.;
RT   "Isolation and characterization of Chinese hamster ovary cell mutants
RT   deficient in acyl-coenzyme A:cholesterol acyltransferase activity.";
RL   J. Biol. Chem. 263:274-282(1988).
//
RX   PubMed=6105157; DOI=10.1016/S0021-9258(19)43901-X;
RA   Chang T.-Y., Limanek J.S.;
RT   "Regulation of cytosolic acetoacetyl coenzyme A thiolase,
RT   3-hydroxy-3-methylglutaryl coenzyme A synthase,
RT   3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase
RT   by low density lipoprotein and by 25-hydroxycholesterol in Chinese
RT   hamster ovary cells.";
RL   J. Biol. Chem. 255:7787-7795(1980).
//
RX   PubMed=8898195; DOI=10.1016/S0092-8674(00)81362-8;
RA   Hua X.-X., Nohturfft A., Goldstein J.L., Brown M.S.;
RT   "Sterol resistance in CHO cells traced to point mutation in SREBP
RT   cleavage-activating protein.";
RL   Cell 87:415-426(1996).
//