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Cellosaurus RIN 1046-38 (CVCL_U435)

[Text version]
Cell line name RIN 1046-38
Synonyms RIN-1046-38; RIN1046-38; RINr1046-38; 1046-38; RIN-38; RIN 38
Accession CVCL_U435
Resource Identification Initiative To cite this cell line use: RIN 1046-38 (RRID:CVCL_U435)
Comments Characteristics: Secretes insulin (PubMed=1701127; PubMed=2879852).
Characteristics: Loses glucose responsiveness as well as GLUT2 and glucokinase expression with time in culture (PubMed=1701127; PubMed=8157682).
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH.
Hierarchy Parent: CVCL_D163 (RIN-r)
Children:
CVCL_C1JK (betaG 18/3E1)CVCL_C1JU (betaG I/17)CVCL_C1KE (RIN 100/1)
CVCL_C1KF (RIN 100/2)CVCL_C1KG (RIN 100/6)CVCL_C1KH (RIN 30/10)
CVCL_C1KI (RIN 30/7)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/r/cell-lines-detail-102.html
Publications

PubMed=2879852; DOI=10.1172/JCI112819
Philippe J., Chick W.L., Habener J.F.
Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines.
J. Clin. Invest. 79:351-358(1987)

PubMed=1701127; DOI=10.1210/endo-127-6-2779
Clark S.A., Burnham B.L., Chick W.L.
Modulation of glucose-induced insulin secretion from a rat clonal beta-cell line.
Endocrinology 127:2779-2788(1990)

PubMed=2284010; DOI=10.1210/mend-4-7-990
Fiedorek F.T. Jr., Carnaghi L.R., Giddings S.J.
Selective expression of the insulin I gene in rat insulinoma-derived cell lines.
Mol. Endocrinol. 4:990-999(1990)

PubMed=1505450; DOI=10.1210/endo.131.3.1505450
Fiedorek F.T. Jr., Parkinson D.
Carboxypeptidase H processing and secretion in rat clonal beta-cell lines.
Endocrinology 131:1054-1062(1992)

PubMed=8157682; DOI=10.1016/S0021-9258(19)78155-1
Ferber S., BeltrandelRio H., Johnson J.H., Noel R.J., Cassidy L.E., Clark S.A., Becker T.C., Hughes S.D., Newgard C.B.
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.
J. Biol. Chem. 269:11523-11529(1994)

PubMed=9166666; DOI=10.2337/diab.46.6.958
Clark S.A., Quaade C., Constandy H., Hansen P., Halban P.A., Ferber S., Newgard C.B., Normington K.
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
Diabetes 46:958-967(1997)

PubMed=9166667; DOI=10.2337/diab.46.6.968
Hohmeier H.-E., BeltrandelRio H., Clark S.A., Henkel-Rieger R., Normington K., Newgard C.B.
Regulation of insulin secretion from novel engineered insulinoma cell lines.
Diabetes 46:968-977(1997)

PubMed=9549052; DOI=10.1007/BF02778148
Rodriguez-Pena M.S., Collins R., Woodard C., Spiegel A.M.
Decreased insulin content and secretion in RIN 1046-38 cells overexpressing alpha 2-adrenergic receptors.
Endocrine 7:255-260(1997)

Cross-references
Encyclopedic resources Wikidata; Q54950468
Entry history
Entry creation03-Feb-2014
Last entry update29-Jun-2023
Version number12