ID   Huh-7-Lunet
AC   CVCL_U459
SY   Huh-7 Lunet; Huh-7/Lunet; Huh7-Lunet; Huh7Lunet; Huh7L; Huh-7-Luc-Neo-ET
DR   BTO; BTO:0005725
DR   cancercelllines; CVCL_U459
DR   Wikidata; Q54896854
RX   PubMed=15596831;
RX   PubMed=17079281;
RX   PubMed=17552027;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0336 ! Huh-7
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 16
//
RX   PubMed=15596831; DOI=10.1128/JVI.79.1.380-392.2005;
RA   Friebe P., Boudet J., Simorre J.-P., Bartenschlager R.F.W.;
RT   "Kissing-loop interaction in the 3' end of the hepatitis C virus
RT   genome essential for RNA replication.";
RL   J. Virol. 79:380-392(2005).
//
RX   PubMed=17079281; DOI=10.1128/JVI.01534-06;
RA   Koutsoudakis G., Herrmann E., Kallis S., Bartenschlager R.F.W.,
RA   Pietschmann T.;
RT   "The level of CD81 cell surface expression is a key determinant for
RT   productive entry of hepatitis C virus into host cells.";
RL   J. Virol. 81:588-598(2007).
//
RX   PubMed=17552027; DOI=10.3748/wjg.v13.i17.2442;
RA   Duverlie G., Wychowski C.;
RT   "Cell culture systems for the hepatitis C virus.";
RL   World J. Gastroenterol. 13:2442-2445(2007).
//