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Cellosaurus SK-MEL-27-2 (CVCL_U914)

[Text version]

Cell line name SK-MEL-27-2
Synonyms SKMEL-27-2
Accession CVCL_U914
Resource Identification Initiative To cite this cell line use: SK-MEL-27-2 (RRID:CVCL_U914)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=21725359).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6030 (SK-MEL-27)
Sex of cell Female
Age at sampling 52Y
Category Cancer cell line

PubMed=21725359; DOI=10.1038/onc.2011.250
Xing F., Persaud Y., Pratilas C.A., Taylor B.S., Janakiraman M., She Q.-B., Gallardo H., Liu C., Merghoub T., Hefter B., Dolgalev I., Viale A.J., Heguy A., de Stanchina E., Cobrinik D., Bollag G., Wolchok J.D., Houghton A.N., Solit D.B.
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Oncogene 31:446-457(2012)

Encyclopedic resources Wikidata; Q54954002
Polymorphism and mutation databases Cosmic; 1669143
Entry history
Entry creation16-Apr-2014
Last entry update20-May-2021
Version number9