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Cellosaurus AILNCaP (CVCL_U984)

[Text version]

Cell line name AILNCaP
Synonyms AI LNCaP; AI-LNCaP; Androgen-Independent LNCaP
Accession CVCL_U984
Resource Identification Initiative To cite this cell line use: AILNCaP (RRID:CVCL_U984)
Sequence variations Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=16931574; DOI=10.1210/me.2006-0033
Inoue T., Yoshida T., Shimizu Y., Kobayashi T., Yamasaki T., Toda Y., Segawa T., Kamoto T., Nakamura E., Ogawa O.
Requirement of androgen-dependent activation of protein kinase Czeta for androgen-dependent cell proliferation in LNCaP Cells and its roles in transition to androgen-independent cells.
Mol. Endocrinol. 20:3053-3069(2006)

Cross-references
Ontologies BTO; BTO:0004799
Other Wikidata; Q54748998
Entry history
Entry creation16-Apr-2014
Last entry update20-May-2021
Version number12